Detection of a novel and highly divergent coronavirus from asian leopard cats and chinese ferret badgers in southern china
Identifieur interne : 003B77 ( Main/Exploration ); précédent : 003B76; suivant : 003B78Detection of a novel and highly divergent coronavirus from asian leopard cats and chinese ferret badgers in southern china
Auteurs : B. Q. Dong [République populaire de Chine] ; W. Liu [République populaire de Chine] ; X. H. Fan [République populaire de Chine] ; D. Vijaykrishna [Hong Kong] ; X. C. Tang [Hong Kong] ; F. Gao [République populaire de Chine] ; L. F. Li [Hong Kong] ; G. J. Li [République populaire de Chine] ; J. X. Zhang [Hong Kong] ; L. Q. Yang [République populaire de Chine] ; L. L. M. Poon [Hong Kong] ; S. Y. Zhang [République populaire de Chine] ; J. S. M. Peiris [Hong Kong] ; G. J. D. Smith [Hong Kong] ; H. Chen [Hong Kong] ; Y. Guan [Hong Kong]Source :
- Journal of virology [ 0022-538X ] ; 2007.
Descripteurs français
- KwdFr :
- Animaux, Chine, Coronavirus (), Coronavirus (enzymologie), Coronavirus (génétique), Coronavirus (isolement et purification), Données de séquences moléculaires, Felidae (virologie), Flambées de maladies (histoire), Histoire du 21ème siècle, Humains, Mustelidae (virologie), Phylogénie, Protéines virales (génétique), RNA helicases (génétique), RNA replicase (génétique), Syndrome respiratoire aigu sévère (histoire), Syndrome respiratoire aigu sévère (virologie), Syndrome respiratoire aigu sévère (épidémiologie), Séquence nucléotidique, Évolution moléculaire.
- MESH :
- enzymologie : Coronavirus.
- génétique : Coronavirus, Protéines virales, RNA helicases, RNA replicase.
- histoire : Flambées de maladies, Syndrome respiratoire aigu sévère.
- isolement et purification : Coronavirus.
- virologie : Felidae, Mustelidae, Syndrome respiratoire aigu sévère.
- épidémiologie : Syndrome respiratoire aigu sévère.
- Pascal (Inist)
- Wicri :
- geographic : République populaire de Chine.
English descriptors
- KwdEn :
- Animal, Animals, Base Sequence, China, Coronavirus, Coronavirus (classification), Coronavirus (enzymology), Coronavirus (genetics), Coronavirus (isolation & purification), Detection, Disease Outbreaks (history), Evolution, Molecular, Felidae (virology), Ferret, History, 21st Century, Humans, Molecular Sequence Data, Mustelidae (virology), Phylogeny, RNA Helicases (genetics), RNA Replicase (genetics), Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (history), Severe Acute Respiratory Syndrome (virology), Viral Proteins (genetics), Virology.
- MESH :
- chemical , genetics : RNA Helicases, RNA Replicase, Viral Proteins.
- geographic : China.
- classification : Coronavirus.
- enzymology : Coronavirus.
- epidemiology : Severe Acute Respiratory Syndrome.
- genetics : Coronavirus.
- history : Disease Outbreaks, Severe Acute Respiratory Syndrome.
- isolation & purification : Coronavirus.
- virology : Felidae, Mustelidae, Severe Acute Respiratory Syndrome.
- Animals, Base Sequence, Evolution, Molecular, History, 21st Century, Humans, Molecular Sequence Data, Phylogeny.
Abstract
Since an outbreak of severe acute respiratory syndrome (SARS) was averted in 2004, many novel coronaviruses have been recognized from different species, including humans. Bats have provided the most diverse assemblages of coronaviruses, suggesting that they may be the natural reservoir. Continued virological surveillance has proven to be the best way to avert this infectious disease at the source. Here we provide the first description of a previously unidentified coronavirus lineage detected from wild Asian leopard cats (Prionailurus bengalensis) and Chinese ferret badgers (Melogale moschata) during virological surveillance in southern China. Partial genome analysis revealed a typical coronavirus genome but with a unique putative accessory gene organization. Phylogenetic analyses revealed that the envelope, membrane, and nucleoprotein structural proteins and the two conserved replicase domains, putative RNA-dependent RNA polymerase and RNA helicase, of these novel coronaviruses were most closely related to those of group 3 coronaviruses identified from birds, while the spike protein gene was most closely related to that of group 1 coronaviruses from mammals. However, these viruses always fell into an outgroup phylogenetic relationship with respect to other coronaviruses and had low amino acid similarity to all known coronavirus groups, indicating that they diverged early in the evolutionary history of coronaviruses. These results suggest that these viruses may represent a previously unrecognized evolutionary pathway, or possibly an unidentified coronavirus group. This study demonstrates the importance of systematic virological surveillance in market animals for understanding the evolution and emergence of viruses with infectious potential.
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Affiliations:
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Le document en format XML
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Liu</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangxi Center for Disease Control and Prevention, Guangxi Medical University</s1><s2>Nanning 530021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Nanning 530021</wicri:noRegion></affiliation></author><author><name sortKey="Fan, X H" sort="Fan, X H" uniqKey="Fan X" first="X. H." last="Fan">X. H. Fan</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Microbiology and Immunology, Guangxi Medical University</s1><s2>Nanning 530021</s2><s3>CHN</s3><sZ>3 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Nanning 530021</wicri:noRegion></affiliation></author><author><name sortKey="Vijaykrishna, D" sort="Vijaykrishna, D" uniqKey="Vijaykrishna D" first="D." last="Vijaykrishna">D. 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Tang</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Gao, F" sort="Gao, F" uniqKey="Gao F" first="F." last="Gao">F. Gao</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangxi Center for Disease Control and Prevention, Guangxi Medical University</s1><s2>Nanning 530021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Nanning 530021</wicri:noRegion></affiliation></author><author><name sortKey="Li, L F" sort="Li, L F" uniqKey="Li L" first="L. F." last="Li">L. F. Li</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Li, G J" sort="Li, G J" uniqKey="Li G" first="G. J." last="Li">G. J. Li</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Microbiology and Immunology, Guangxi Medical University</s1><s2>Nanning 530021</s2><s3>CHN</s3><sZ>3 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Nanning 530021</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, J X" sort="Zhang, J X" uniqKey="Zhang J" first="J. X." last="Zhang">J. X. Zhang</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Yang, L Q" sort="Yang, L Q" uniqKey="Yang L" first="L. Q." last="Yang">L. Q. Yang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangxi Center for Disease Control and Prevention, Guangxi Medical University</s1><s2>Nanning 530021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Nanning 530021</wicri:noRegion></affiliation></author><author><name sortKey="Poon, L L M" sort="Poon, L L M" uniqKey="Poon L" first="L. L. M." last="Poon">L. L. M. 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M." last="Peiris">J. S. M. Peiris</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Smith, G J D" sort="Smith, G J D" uniqKey="Smith G" first="G. J. D." last="Smith">G. J. D. Smith</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Chen, H" sort="Chen, H" uniqKey="Chen H" first="H." last="Chen">H. Chen</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Guan, Y" sort="Guan, Y" uniqKey="Guan Y" first="Y." last="Guan">Y. Guan</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">07-0486092</idno><date when="2007">2007</date><idno type="stanalyst">PASCAL 07-0486092 INIST</idno><idno type="RBID">Pascal:07-0486092</idno><idno type="wicri:Area/PascalFrancis/Corpus">000339</idno><idno type="wicri:Area/PascalFrancis/Curation">000650</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000389</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000389</idno><idno type="wicri:doubleKey">0022-538X:2007:Dong B:detection:of:a</idno><idno type="wicri:Area/Main/Merge">003D36</idno><idno type="wicri:source">PMC</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1933311</idno><idno type="RBID">PMC:1933311</idno><idno type="wicri:Area/Pmc/Corpus">000716</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000716</idno><idno type="wicri:Area/Pmc/Curation">000716</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000716</idno><idno type="wicri:Area/Pmc/Checkpoint">000F75</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000F75</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:17459938</idno><idno type="wicri:Area/PubMed/Corpus">001E37</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001E37</idno><idno type="wicri:Area/PubMed/Curation">001E37</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001E37</idno><idno type="wicri:Area/PubMed/Checkpoint">001E33</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001E33</idno><idno type="wicri:Area/Ncbi/Merge">001939</idno><idno type="wicri:Area/Ncbi/Curation">001939</idno><idno type="wicri:Area/Ncbi/Checkpoint">001939</idno><idno type="wicri:doubleKey">0022-538X:2007:Dong B:detection:of:a</idno><idno type="wicri:Area/Main/Merge">003873</idno><idno type="wicri:Area/Main/Curation">003B77</idno><idno type="wicri:Area/Main/Exploration">003B77</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Detection of a novel and highly divergent coronavirus from asian leopard cats and chinese ferret badgers in southern china</title><author><name sortKey="Dong, B Q" sort="Dong, B Q" uniqKey="Dong B" first="B. Q." last="Dong">B. Q. Dong</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangxi Center for Disease Control and Prevention, Guangxi Medical University</s1><s2>Nanning 530021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Nanning 530021</wicri:noRegion></affiliation></author><author><name sortKey="Liu, W" sort="Liu, W" uniqKey="Liu W" first="W." last="Liu">W. Liu</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangxi Center for Disease Control and Prevention, Guangxi Medical University</s1><s2>Nanning 530021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Nanning 530021</wicri:noRegion></affiliation></author><author><name sortKey="Fan, X H" sort="Fan, X H" uniqKey="Fan X" first="X. H." last="Fan">X. H. Fan</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Microbiology and Immunology, Guangxi Medical University</s1><s2>Nanning 530021</s2><s3>CHN</s3><sZ>3 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Nanning 530021</wicri:noRegion></affiliation></author><author><name sortKey="Vijaykrishna, D" sort="Vijaykrishna, D" uniqKey="Vijaykrishna D" first="D." last="Vijaykrishna">D. Vijaykrishna</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Tang, X C" sort="Tang, X C" uniqKey="Tang X" first="X. C." last="Tang">X. C. Tang</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Gao, F" sort="Gao, F" uniqKey="Gao F" first="F." last="Gao">F. Gao</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangxi Center for Disease Control and Prevention, Guangxi Medical University</s1><s2>Nanning 530021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Nanning 530021</wicri:noRegion></affiliation></author><author><name sortKey="Li, L F" sort="Li, L F" uniqKey="Li L" first="L. F." last="Li">L. F. Li</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Li, G J" sort="Li, G J" uniqKey="Li G" first="G. J." last="Li">G. J. Li</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Microbiology and Immunology, Guangxi Medical University</s1><s2>Nanning 530021</s2><s3>CHN</s3><sZ>3 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Nanning 530021</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, J X" sort="Zhang, J X" uniqKey="Zhang J" first="J. X." last="Zhang">J. X. Zhang</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Yang, L Q" sort="Yang, L Q" uniqKey="Yang L" first="L. Q." last="Yang">L. Q. Yang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangxi Center for Disease Control and Prevention, Guangxi Medical University</s1><s2>Nanning 530021</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Nanning 530021</wicri:noRegion></affiliation></author><author><name sortKey="Poon, L L M" sort="Poon, L L M" uniqKey="Poon L" first="L. L. M." last="Poon">L. L. M. Poon</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, S Y" sort="Zhang, S Y" uniqKey="Zhang S" first="S. Y." last="Zhang">S. Y. Zhang</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>School of Life Sciences, East China Normal University</s1><s2>Shanghai 200062</s2><s3>CHN</s3><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai 200062</wicri:noRegion></affiliation></author><author><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J. S. M." last="Peiris">J. S. M. Peiris</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Smith, G J D" sort="Smith, G J D" uniqKey="Smith G" first="G. J. D." last="Smith">G. J. D. Smith</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Chen, H" sort="Chen, H" uniqKey="Chen H" first="H." last="Chen">H. Chen</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Guan, Y" sort="Guan, Y" uniqKey="Guan Y" first="Y." last="Guan">Y. Guan</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Journal of virology</title><title level="j" type="abbreviated">J. virol.</title><idno type="ISSN">0022-538X</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of virology</title><title level="j" type="abbreviated">J. virol.</title><idno type="ISSN">0022-538X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term><term>Animals</term><term>Base Sequence</term><term>China</term><term>Coronavirus</term><term>Coronavirus (classification)</term><term>Coronavirus (enzymology)</term><term>Coronavirus (genetics)</term><term>Coronavirus (isolation & purification)</term><term>Detection</term><term>Disease Outbreaks (history)</term><term>Evolution, Molecular</term><term>Felidae (virology)</term><term>Ferret</term><term>History, 21st Century</term><term>Humans</term><term>Molecular Sequence Data</term><term>Mustelidae (virology)</term><term>Phylogeny</term><term>RNA Helicases (genetics)</term><term>RNA Replicase (genetics)</term><term>Severe Acute Respiratory Syndrome (epidemiology)</term><term>Severe Acute Respiratory Syndrome (history)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Viral Proteins (genetics)</term><term>Virology</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Chine</term><term>Coronavirus ()</term><term>Coronavirus (enzymologie)</term><term>Coronavirus (génétique)</term><term>Coronavirus (isolement et purification)</term><term>Données de séquences moléculaires</term><term>Felidae (virologie)</term><term>Flambées de maladies (histoire)</term><term>Histoire du 21ème siècle</term><term>Humains</term><term>Mustelidae (virologie)</term><term>Phylogénie</term><term>Protéines virales (génétique)</term><term>RNA helicases (génétique)</term><term>RNA replicase (génétique)</term><term>Syndrome respiratoire aigu sévère (histoire)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Syndrome respiratoire aigu sévère (épidémiologie)</term><term>Séquence nucléotidique</term><term>Évolution moléculaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA Helicases</term><term>RNA Replicase</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>China</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus</term><term>Protéines virales</term><term>RNA helicases</term><term>RNA replicase</term></keywords><keywords scheme="MESH" qualifier="histoire" xml:lang="fr"><term>Flambées de maladies</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="history" xml:lang="en"><term>Disease Outbreaks</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Felidae</term><term>Mustelidae</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Felidae</term><term>Mustelidae</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Base Sequence</term><term>Evolution, Molecular</term><term>History, 21st Century</term><term>Humans</term><term>Molecular Sequence Data</term><term>Phylogeny</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term><term>Chine</term><term>Coronavirus</term><term>Données de séquences moléculaires</term><term>Détection</term><term>Animal</term><term>Chine</term><term>Furet</term><term>Histoire du 21ème siècle</term><term>Humains</term><term>Phylogénie</term><term>Séquence nucléotidique</term><term>Virologie</term><term>Évolution moléculaire</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Since an outbreak of severe acute respiratory syndrome (SARS) was averted in 2004, many novel coronaviruses have been recognized from different species, including humans. Bats have provided the most diverse assemblages of coronaviruses, suggesting that they may be the natural reservoir. Continued virological surveillance has proven to be the best way to avert this infectious disease at the source. Here we provide the first description of a previously unidentified coronavirus lineage detected from wild Asian leopard cats (Prionailurus bengalensis) and Chinese ferret badgers (Melogale moschata) during virological surveillance in southern China. Partial genome analysis revealed a typical coronavirus genome but with a unique putative accessory gene organization. Phylogenetic analyses revealed that the envelope, membrane, and nucleoprotein structural proteins and the two conserved replicase domains, putative RNA-dependent RNA polymerase and RNA helicase, of these novel coronaviruses were most closely related to those of group 3 coronaviruses identified from birds, while the spike protein gene was most closely related to that of group 1 coronaviruses from mammals. However, these viruses always fell into an outgroup phylogenetic relationship with respect to other coronaviruses and had low amino acid similarity to all known coronavirus groups, indicating that they diverged early in the evolutionary history of coronaviruses. These results suggest that these viruses may represent a previously unrecognized evolutionary pathway, or possibly an unidentified coronavirus group. This study demonstrates the importance of systematic virological surveillance in market animals for understanding the evolution and emergence of viruses with infectious potential.</div></front></TEI><affiliations><list><country><li>Hong Kong</li><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Dong, B Q" sort="Dong, B Q" uniqKey="Dong B" first="B. Q." last="Dong">B. Q. Dong</name></noRegion><name sortKey="Fan, X H" sort="Fan, X H" uniqKey="Fan X" first="X. H." last="Fan">X. H. Fan</name><name sortKey="Gao, F" sort="Gao, F" uniqKey="Gao F" first="F." last="Gao">F. Gao</name><name sortKey="Li, G J" sort="Li, G J" uniqKey="Li G" first="G. J." last="Li">G. J. Li</name><name sortKey="Liu, W" sort="Liu, W" uniqKey="Liu W" first="W." last="Liu">W. Liu</name><name sortKey="Yang, L Q" sort="Yang, L Q" uniqKey="Yang L" first="L. Q." last="Yang">L. Q. Yang</name><name sortKey="Zhang, S Y" sort="Zhang, S Y" uniqKey="Zhang S" first="S. Y." last="Zhang">S. Y. Zhang</name></country><country name="Hong Kong"><noRegion><name sortKey="Vijaykrishna, D" sort="Vijaykrishna, D" uniqKey="Vijaykrishna D" first="D." last="Vijaykrishna">D. Vijaykrishna</name></noRegion><name sortKey="Chen, H" sort="Chen, H" uniqKey="Chen H" first="H." last="Chen">H. Chen</name><name sortKey="Guan, Y" sort="Guan, Y" uniqKey="Guan Y" first="Y." last="Guan">Y. Guan</name><name sortKey="Li, L F" sort="Li, L F" uniqKey="Li L" first="L. F." last="Li">L. F. Li</name><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J. S. M." last="Peiris">J. S. M. Peiris</name><name sortKey="Poon, L L M" sort="Poon, L L M" uniqKey="Poon L" first="L. L. M." last="Poon">L. L. M. Poon</name><name sortKey="Smith, G J D" sort="Smith, G J D" uniqKey="Smith G" first="G. J. D." last="Smith">G. J. D. Smith</name><name sortKey="Tang, X C" sort="Tang, X C" uniqKey="Tang X" first="X. C." last="Tang">X. C. Tang</name><name sortKey="Zhang, J X" sort="Zhang, J X" uniqKey="Zhang J" first="J. X." last="Zhang">J. X. Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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